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KMID : 0881720100250030226
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Journal of Food Hygiene and Safety
2010 Volume.25 No. 3 p.226 ~ p.231
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Analysis of Medroxyprogesterone Acetate in Meats
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Lee Yoon-Ae
Shim Jee-Youn
Lee Ryun-Kyung
Kim Seung-Hwan
Oh Hyun-Sook
Cho Tae-Yong
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Abstract
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We aimed at the monitoring medroxyprogesterone acetate (MPA) residue amount in meats and confirmed the safety of its residue in meats. Optimized condition for analytical and instrumental methods was obtained by method validation. The limit of detection (LOD) and limit of quantification (LOQ) were validated at 1.5 and 5.0 ug/kg, respectively. The calibration curve showed good linearity (r2 = 0.9968) within the concentration range of 5.0~50.0 ug/kg. We selected progesterone-d9 for internal standard, The recoveries in fortified meat ranged from 67.5 to 109.56% at the 3 spiking levels. As the regulation of MPA analysis method used by LC-MS/MS on other products have established. We selected 3 species of farm stock products (cattle, pig, chicken) and purchased at the markets of seven major cities. The total 196 of meat including 46 of domestic beef, 43 of import beef, 60 of domestic pork, 12 of import pork and 35 of domestic chicken. No residue of synthetic growth hormones were detected in cattle, pig and chicken samples tested.
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KEYWORD
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Meats, growth hormone, veterinary drug, medroxyprogesterone acetate, internal standard
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